The Cardiovascular Imaging Core Laboratory provides high-quality quantitative and qualitative cardiovascular imaging analysis for large scale cardiovascular clinical trials and experimental protocols.


The CICL tailors our full service offerings to best meet the specific needs of each study. In addition to providing high-quality quantitative and qualitative imaging analysis, the CICL offers complete on-site and off-site training including live demonstrations, site instruction manuals, and site certification. The CICL works closely with Sponsors to define the most appropriate Scope of Work for each project. Specific image processing and analytic services include comprehensive analysis of :

  • Echocardiograms (echo)
  • Cardiac computed tomography (CT)
  • Cardiac magnetic resonance imaging (MRI)
  • Arterial tonometry based analyses of pulse waveforms

Scott D. Solomon, MD serves as Director of the CICL and is an Associate Professor of Medicine at Harvard Medical School and Director of the Non-Invasive Cardiac Laboratory at Brigham and Women’s Hospital. Dr. Solomon and the CICL have focused on the non-invasive assessment of cardiac structure and function in patients with or at risk for heart failure or ischemic heart disease and the effects of interventions on attenuating left ventricular remodeling and dysfunction. He has published over 150 scientific papers, chapters, reviews, and editorials, written "Essential Echocardiography" and "Atlas of Echocardiography", has coauthored the Guidelines for Chamber Quantification,  Guidelines for Right Ventricular Assessment, and Guidelines for Echocardiography in Clinical Trials for the American Society of Echocardiography. Dr. Solomon serves as an Associate Editor at Circulation and  is a world-renowned clinical trialist who maintains an active leadership role for numerous multi-center clinical trials.

Recent CICL Publications

Solomon SD, Foster E, Bourgoun M, Shah A, Viloria E, Brown M, Hall WJ, Pfeffer MA, Moss AJ for the MADIT-CRT Investigators. Effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: MADIT-CRT. Circulation. In Press.

Shin SH, Hung CL, Hassanein AH, Verma A, Bourgoun M, Kober L, Ghali JK, Velazquez EJ, Califf R, Pfeffer MA, Solomon SD. Mechanical Dyssynchrony after Myocardial Infarction in Patients with Left Ventricular Dysfunction, Heart Failure, or Both. Circulation. 2010;121(9):1096-103.

Wu JC, Ho CY, Skali H, Abichandani R, Wilcox WR, Banikazemi M, Packman S, Sims K, Solomon SD. Cardiovascular Manifestations of Fabry Disease: relationships between left ventricular hypertrophy, disease severity, and alpha-galactosidase A activity. Eur Heart J. 2010 Jan 7. [Epub ahead of print]

Solomon SD, Verma A, Desai A, Hassanein A, Izzo J, Oparil S, Lacourciere Y, Lee J, Seifu Y, Hilkert R, Rocha R, Pitt B. Effect of intensive versus standard blood pressure lowering on diastolic function in patients with uncontrolled hypertension and diastolic dysfunction. Hypertension. 2010;55(2):241-8.

Moss AJ, Hall WJ, Cannom SD, Klein H, Brown MW, Daubert JP, Estes NAM, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W for the MADIT-CRT Trial Investigators. Reduction in the risk of heart failure events with preventive cardiac resynchronization therapy. N Engl J Med 2009; 361(14):1394-6.

Solomon SD, Appelbaum E, Manning WJ, Verma A, Berglund T, Lukashevich V, Cherif-Papst C, Smith BA, Dahlof B for the Aliskiren in left ventricular hypertrophy trial investigators. Effect of the direct renin inhibitor aliksiren, the angiotensin receptor blocker losartan, or both, on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009;119(4):530-7.

Meris A, Amigoni M, Uno H, Thune JJ, Verma A, Køber L, Bourgoun M, McMurray JJ, Velazquez EJ, Maggioni AP, Ghali J, Arnold JM, Zelenkofske S, Pfeffer MA, Solomon SD. Left atrial remodelling in patients with myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALIANT Echo Study. Eur Heart J. 2009;30(1):56-65.

Solomon SD, Janardhanan R, Verma A, Bourgoun M, Daley WL, Purkayastha D, LaCourcier Y, Hippler SE, Fields H, Naqvi TZ, Mulvagh SL, Arnold JMO, Thomas JD, Zile MR, Aurigemma MD for the Valsartan in Diastolic Dysfunction (VALIDD) Investigators. The influence of angiotensin receptor blockade and blood pressure lowering on diastolic function in patients with hypertension and diastolic dysfunction. Lancet. 2007;369:2079-87.

For all inquiries regarding new projects

Scott D. Solomon, MD, Director
Cardiovascular Imaging Core Laboratory
Brigham and Women’s Hospital
Harvard Medical School
75 Francis Street, Boston, MA 02115
Phone: +1.857.307.1960
Fax: +1.617.582.6027
Email: ssolomon@rics.bwh.harvard.edu

For general inquiries regarding CICL services

Tracey Cole
Cardiovascular Imaging Core Laboratory
20 Shattuck St, PBB Ground Rm A100
Boston, MA 02115
Phone: +1.617.525.6730
Fax: +1.617.582.6027
Email: tcole2@partners.org
CICL Main Hotline: +1.617.525.6730
CICL Main E-mail: echocore@rics.bwh.harvard.edu